Supermodel Makeover by Lauren Luke (Europe) (En,Fr,De,It)

Shichida Shiki Training – Unou Tanren Unotan DS – Shun Kan Shoubu! Kiokuryoku (Japan)

SimCity DS – The Ultimate City Simulator (Japan)

Super Black Bass – Kitahankyuu o Tsuru (Japan)

Shion no Ou – The Flowers of Hard Blood (Japan)

Shrek – Forever After (Europe) (En,Fr) (NDSi Enhanced)

Shin chan e i Colori Magici! (Italy)

Space Camp (Europe) (En,Fr,De,Es,It)

Sam Power – Firefighter (Europe) (En,Fr,De,Es,It,Nl,Sv,No,Da)

So Blonde – Back to the Island (Europe) (En,Fr,De,Es,It)

Samantha Swift and the Hidden Roses of Athena (Europe) (En,Nl)

Strawberry Shortcake – The Four Seasons Cake (Europe) (En,Fr,De,Es,It,Nl)

Shiseido Beauty Solution Kaihatsu Center Kanshuu – Project Beauty (Japan)

Super Fahrschule (Germany)

Summon Night – Twin Age (USA)

Simple DS Series Vol. 8 – The Kanshikikan – Kinkyuu Shutsudou! Jiken Genba o Touch Seyo! (Japan)

Shrek – Ogritos y Drasnos (Spain)

Solatorobo – Sorekara Coda e (Japan) (NDSi Enhanced)

Sight Training – Enjoy Exercising and Relaxing Your Eyes (Europe) (En,Fr,De,Es,It)

Sega Casino (Europe) (En,Fr,De,Es,It)

Simple DS Series Vol. 19 – Yareba Dekiru! – The Micro Step Gijutsu de Oboeru Eitango (Japan)

Solitaire (Europe) (En,Fr,De,Es,It)

Simple DS Series Vol. 41 – The Bakudan Shorihan (Japan)

Shugo Chara! – 3-tsu no Tamago to Koisuru Joker (Japan)