Super Kaseki Horider (Japan) (NDSi Enhanced)

SpongeBob SquarePants – Creature from the Krusty Krab (USA)

Shaun the Sheep (USA) (En,Ja,Fr,De,Es,It)

Sims 2, The – Castaway (USA) (En,Fr,De,Es,It,Nl,Pt)

Spider-Man – Edge of Time (Europe) (En,Fr,De,Es,It)

Spider-Man – Friend or Foe (Europe)

Super Collapse! 3 (USA)

SimAnimals (USA) (En,Fr,De,Es,It,Nl,Pt,Sv,No,Da)

Shrek – Forever After (USA) (En,Fr) (NDSi Enhanced)

Scribblenauts (Europe) (En,Sv,No,Da,Fi)

Spider-Man 2 (Europe) (En,Fr,De,Es,It)

Santa Claus is Comin’ to Town (USA)

Spider-Man 3 (France)

Space Invaders Revolution (USA) (En,Fr,De,Es,It)

Shrek the Third (Europe)

Spider-Man – Web of Shadows (Europe) (En,Fr,De)

Spider-Man – Web of Shadows (Europe) (Es,It)

Science Papa (Europe) (En,Fr,De,Es,It)

Star Wars – Episode III – Revenge of the Sith (USA) (En,Fr,De,Es,It,Nl)

SpongeBob SquarePants featuring Nicktoons – Globs of Doom (USA) (En,Fr)

Squishy Tank (USA)

Spectrobes (USA) (En,Fr,De,Es,It)

SpongeBob’s Boating Bash (USA) (NDSi Enhanced)

Star Wars – Lethal Alliance (Europe) (En,Fr,De,Es,It)